There are loads of fantastic American comics doing well right now, but they're webcomics, or children's graphic novels.
The age of floppies dominated by the big two is unlikely to come back around, in my opinion, because the format is expensive and the distribution model is exclusionary. If people can read great comics on their phones, why would they traipse out into some gloomy comic book shop to buy expensive, yet cheaply-printed floppies full of ads?
The way people consume comics is changing, and I think we're going to see the same pattern as we've seen in parts of Asia, where webcomics become the way people read serialised comics, rather than floppies. There'll still be books, just like how floppies get collected into trades, larger webcomics get sold as books, either through publishers or self-publishing.
It's not necessarily a bad thing. Webcomics allow diverse creators who have been gatekept out of the industry to have a shot at making it big based on storytelling and art skill and market appeal, and they're much more relevant to modern young adults than the rather cringe attempts by the big two in recent years to make stuff for that audience. That said, I don't think the US will be as big a dominating force in comics any more. It'll still be a powerhouse due to just... having a lot of people and so inevitably a lot of creators, but we're going to see creators much more spread out around the world.