Even in my Q&A's, I try to fit that into canon. But ironically enough I'm fine with characters knowing they're in a comic, but if I were to ever address it, I'd have them be like "Oh... I guess this is how our particular reality works and there's another reality beyond that. That's honestly the least crazy thing I've heard all day".
I think due to me having EVERYTHING be connected, I'm obligated to address it; but I'd want 4th wall breaking characters to feel like you're going up against someone with street smarts? Like "We're above you, but due to us not breaking free from this plane, we're no different from you, so we can't afford to underestimate you since the narrator could kill us off".