I should first mention that judging by the synopsis, this comic isn't exactly up my alley. I'll try my best to provide an unbiased opinion though.
The art kind of reminds me of old flash games where the characters are superimposed on a background. This is due to the fact that certain things are hand drawn while you also use external assets which causes the styles to clash. Instead of being in the environment you set up, they're on top of it, like a green screen. One way to help minimize this is to not use actual textures (the sky, the floor, AND FOR SURE the real life pictures). Other than that, the art is good. Nothing that stands out, but something people would give a chance when first seeing it. Just a small not on the text bubbles, try not to make them really small.
Before we go on to the characters/plot, I want to talk about the pacing. Each of the first three chapters focus on a character (or two for chapter 1) and then they're immediately thrown together and drive off with the plot. For a story that's supposed to be character driven (at least my assumption from what I've seen so far), I haven't gotten the time to get invested in the characters themselves. I would have preferred if you spent a little more time (even a chapter or two per character) to get a better understanding of what they're about.
Speaking of the story, there's already a huge plot convenience. I can get the characters meeting up in a random towing shop, but not how they were able to escape from not only cop cars, but a police helicopter. Not to mention it was done by getting into a brightly coloured RV and driving down an open road. It's all extremely unbelievable and got a laugh out of me that you probably didn't want. As for the comedy, I cracked a smile for some of the jokes. The humor is silly which is perfect for me, so I'd say to keep it up.
There hasn't been a lot of worldbuilding (so this is going to be a short section), but it looks interesting from what I've seen so far. You were able to incorporate it nicely without making it feel like exposition. The idea itself isn't the most original, but you can do a lot with it.
The characters haven't had a lot of time to develop yet, but you've done a good job at expressing their personalities. They all feel believable and their interactions seem real. Sometimes the dialogue feels a little stiff, but flows well for the most part.
As a final note, I like how how the last page slowly got updated as new characters were introduced.