OHO, I follow a few really awesome stories that have deep, complex relationship angles as their pivot and MAN ALIVE, you will weep.
Joanne's Erie Waters is beautiful, both stylistically and story-wise, and it just finished so you can grab some tissues and tuck in with it to the resolve~
Redemption, which has already been suggested, I also recommend for the intense sad-factor there. It's a ride, man, it's amazing.
And Lily's Interritus is stunningly written with political intrigue and brooding young dignitaries dealing with a plague. There's a couple of heart-wrenching scenes that totally get you at the characters' friendships.