If I ever made a romance or slice of life focused comic, or even something like a mystery or atmospheric horror I'd really consider scroll-based. I think it's a cool format for comics where the timing and detail of a sequence isn't too vital to the action or jokes.
...The thing is though, I'm primarily an action and comedy person, and I think long scroll is pretty bad when you want to use tight timing in a fight or to make a joke really hit. When you do action in long scroll, it's like the whole fight is in this super-dramatic slow motion. It works great if you want that epic feel, but it's quite limiting when all your action scenes have to be in epic slow-mo all the time. Small rows of horisontal panels are an important tool in my arsenal as a comic artist, and it's a shame to have to discard something so useful.
It's also a lot easier for me to make panels for print and then spread them out a bit for Tapas than to make a long scroll comic and then have to tetris the panels into some kind of working page layout if I ever want to make a print edition!