No, the genre doesn't matter in my case, it's just my reading style ( : I know that comics are usually much better when read in bigger chunks, I myself have a very long fantasy series which has a better flow when read at once or at least chapter by chapter. However, as I a reader, I like smaller but more frequent updates to read in between other things. If I have more time, I usually don't read new updates but catch up with some comics I'm not up to date yet which are rotting in my to-read list. If I know that there's going to be a long read, I procrastinate reading a lot 
But again, that's just my reading style, probably each reader has their own so you just do how it's easier for you!
If you start uploading more frequently, readers who prefer to read more content at once will just wait for few updates and read everything once a month or something, so it's not like you'll be losing them. At least that's what some of my readers do.