Hate it, it's annoying, but it's more annoying that I keep getting this joke thrown at me YEARS AFTER the series ended. I mean sure, I get it when it's still active I guess, but it's over now, stop it, find some new material.
Though I may be more tolerant to the reference than other people with Lupus that hear it, because I'm also used to getting TV reference jokes because I also get the "So are you CHINESE or JAPANESE?" joke and clip from King of the Hill when I tell people I'm Lao. Still. To this DAY. That show is old as shit, WHY do you think I have NEVER heard that one before, and how is this show still relevant???
I think I may or may not have ruined some random person's day with the Lupus joke though. Someone texted me, I have no idea who it was probably wrong number, but the message was "So was it Lupus LOL" so I responded with "Yes it was actually." Never got a message back.