You need to pick the main story. Is it horror with comedy elements to lighten the tone, or a comedy with horrific things that happen. Or a horror with two people involved with one another trying to make it through. Fantasy is a setting, not a story. Anything can happen in a fantasy setting. You shouldn't move back and forth from them, there should be a single genre, that can have some elements from the other genres. This allows the audience to know what they are reading and choose accordingly. A horror fan wants horror, a comedic fan wants comedy. They can understand having parts of other stories in the main genre, but they started reading it because of the main genre.