My previous comic Zenchav had a large cast past chapter 9 and changed PoV a lot because I wanted to tell multiple sides of the story, thinking I could write it more like a book. It didn't work well because of webcomic update time, since if you shift PoV you're not going to revisit the other PoV for potentially years. If readers were attached to the original PoV...well... You've lost them, lol.
With my reboot ( Ring Spell) I've made the main cast more of an ensemble cast where the main four are almost always present, and the PoV never really shifts away from them. The plot (showcased through their interactions) is always driving their actions so there's not a single scene where the story isn't moving forward.