I love the art style, your artwork is amazing. Visually, your world seems very carefully planned out. Everything from the setting to the characters really compliment each other. I love the aesthetic and your design choices. Just from that alone, I'm interested in the world and the characters.
The world building and premise seem solid, it's obvious years went into developing all of this. The tier thing while confusing without context, is easy to understand once given an explanation. Another naming convention might be better if you want it to be more self-explanatory.
The little blurb we got of the story was intriguing. For the most part, the panelling and the pacing were good. I agree it was a little unclear the animals were turning into humans. I had to look over that set of panels a few time to figure out what was happening, but other than that, everything was presented clearly and was easy to follow. I also have to agree that the font choices could be better.