As BoomerZ says, it's important for the updates to be big enough for something to happen. If your individual updates are too short, making people feel like "eh" about bothering to click the notifications, or they start just saving your comic up to binge whenever there's a few updates, you won't get that chunk of likes all around the same day you need for visibilty, so it could actually have the opposite of the intended effect.
There's also the fact that if people aren't commenting because pages don't have much to comment on, you won't have as strong a community around your comic, and you'll struggle to build a strong fanbase.
If you're a fast-paced sort of comic. or a gag-focused one, it's probably fine, but on a deeper story-focused comic, single page can be hard because you can easily get entire updates that are just establishing a scene, or showing a transition. Overall, you have to base it on, "if I was reading this, would I feel satisfied with this update? Would I think it was worth my time to click on it? Would there be something to comment on?"