@TheThoughtfulBoxful Innocence preserved!
OP, I'd also like to recommend Winston Rowntree's Subnormality. He really takes advantage of the "infinite canvas" aspect of webcomics. Beautiful work, but not the most commercial.
oh yeah the american remake is shite, im looking at the bleeding anime
Here's an awesome use of the infinite canvas in webcomic : http://english.bouletcorp.com/2013/08/02/the-long-journey/
how about chapter 5 in watchmen, Fearful Symmetry has symetrical page layout ( so page 1 is the mirror of page 28 etc)
you can find out about it here: