If people don't like it, they won't read. You're not out anything. But if you do post, there might be people who like it, so you have everything to gain (unless you were saving it for publishing or something).
Del and I like larger updates so our comic schedule is unusual - we post a bunch over three weeks then take a few weeks off. In between I post chapters of the novel tie in. This means that both versions go for a few weeks without updates, even if something is posted to the account every week. Doesn't align so well with Tapas' algorithm but every time we poll our readers about it, they tell us 2 to 1 not to change anything, so it sure seems like people don't mind waiting for the things they enjoy.