I saw your mention that you were playing D&D with kids now. It's good to see that I did not ruin it for you with my terrible little railroading game that I tried to run here on the forums.
Very very minor spoiler for Spider-Man: Into the Spider-verse ahead...
When Peter B. Parker first describes arriving in a new world and noticing the changes, Clone High is playing on one of the billboard screens. At least Abe and JFK were on that screen. This must be the alternate world in which Clone High was not canceled.
My wife's exposure to Spider-Man consists almost exclusively of watching the other movies. Same goes for our housemate. She might have read a Wikipedia article or two at some point. They somehow had heard of Spider-Ham. I got them to watch the first episode of Marvel Rising with me, so they were familiar with Spider-Gwen (or Ghost-Spider as she is called in that show). They certainly never heard of Prowler or Spider-Man 2099. They both enjoyed it at least as much as me.