I kinda hate it, like it makes me roll my eyes as soon as I see a meme joke.
I don't mind references though to things that are a bit more timeless, the problem with memes now is that they come and go really quickly, if you write it a meme joke in your comic it might seem okay at that specific time but anyone reading your comic a month or even a week from now is gonna cringe.
I think this is kinda okay, even then they have to be really good meme jokes and not just referencing the meme. Also it has to be really clear that the comic is set it 2015 otherwise it would make me think 'Why are the authors jokes really out-dated?'
idk I'd avoid this type of humor all together mainly bc I don't want my comic to feel out dated because of them, you can create a sense of the time/year your comic is set in, in a much better way than using memes.