From writing angle, yep I'm always worried if things are clear for reader (especially as some scenes are in 1st person), sometimes I'd sneak in edits or captions. Thankfully readers haven't complained so guessing its clear enough 
This has been my 1st time making a webcomic, and my page layout ( 'scroll down' pacing) has improved significantly with the newer episodes, I've never got a chance to modify the layouts of the 1st episodes but it does make me feel like I got caught with my pants down "knowing that those 1st episodes would be potential readers' 1st impression of this series" 
Think my biggest worry at the moment is production time while balancing RL duties, guess most here can relate to that,
having too much fun making this series and don't want to stop
Also about two months ago, my laptop's Monitor Colors got messed up, there's a green-ish tint, I've been trying to release an episode once a month, but the rate things going I might have to slow down even more. On positive note, my mom gave me her laptop but the disk space isn't big enough for all the 3d files for comic, so lately I been putting small portions together on her laptop (to see the actual colors, set up lighting, tweak stuff) and then combine the scenes (to render out as jpegs) on my Wacky Colored Laptop, its a challenge and the back and forth gets super confusing and slow, but a makeshift solution until i got the funds to buy a new laptop