Southeast US here.
I can highly recommend MomoCon, as well as Anime Weekend Atlanta. If you've really got your game together DragonCon is a beast and you WILL make money (but hoooboy I hope you like crowds).
If you're in the Washington DC area Small Press Expo is excellent (but it's a lottery system to get tables, you only pay if you get in).
NC area Raleigh SuperCon is great, and I've heard nothing but good stuff about Animazement.
Smaller cons are some of the best for sales though, so google you're local areas and see if there's tiny cons there. Tables are usually hella cheap, and it's easier to make back table/make a profit with such a low overhead cost.