I actually can't say it any better than @CyndiFoster here.
I feel that if you're passionate about the story you're telling it'll carry through your artwork and drive you to do more. I'm passionate about the story I'm telling and yes I have down days, this is when I'm drawing add on stuff and promo stuff for it.
as for the business of it like cyndi said, if there isn't a market for it, make one! The thing the comic industry lacks is diversity and not only on POC, gender, etc but genre's, themes, story types. If you can't find a story you like, make it!
I think its all about what feels right for you and what you're passionate about.