as a reader, likes mean two things to me depending on whether or not I'm new to the series. If I start reading a new series and it has A LOT of pages, I usually only like the ones that really stand out as impressive. In part, this tends to be because I get so absorbed in the story I just want to hurry up and get to the next page! For regular series, I like pages to show appreciation and to help boost a series in the algorithm. Helping others get to the trending section, even if only for a short while, is mah jam. As a reader, comments mean more than a like. If I'm really involved in the series, I try to leave a comment on every page and engage with the community. For series I'm less involved with, I'll leave a comment if I have something to say.
another exception: for gag-a-day comics without a narrative, I'll like the page if I find the joke funny. Simple.
as a creator, I tend to interpret likes the same way (but inversed). If someone likes pages only every now and again, I figure it means they a) read in bursts or b) only like a page if they find it better/more interesting than usual. Comments are more meaningful than likes, but I'd be pretty bummed out if I didn't get any likes. Likes also let me know what times of day tend to be the most successful for posting.