My opinion? Overwhelmingly they're bad.
Not because I find them lazy or low-effort, but because they take away the need for any stylization.
Part of the joy and the appeal of webcomics is the style they're drawn in. Are the lines sharp? Are they gritty? Are there no lines? How is the lighting done? What are the colors like? Are they muted? Bright? Are they in black and white? Halftoned? How are the characters proportioned? How do they move? Are they bendy and cartoonish without clear joints, or are they super staunchly realistic, or are they somewhere in between? Are the expressions realistic, or are they exaggerated with a lot of squash and stretch?
Part of visual storytelling is inherently style. You CAN NOT tell a story in a graphic novel format WITHOUT style. You lose over half of the story elements, between the loss of anatomical style, ability to exaggerate expressions, and the freedom of color and shading.
These 3D webcomics use realistic prefab models that have been slightly edited, and have extremely restrictive rigs that can't be edited without breaking the whole damn thing. The shaders are usually extremely restrictive as well, unless the artist has a lot of experience with making and applying unique shaders to create a style (like with the above comic, Elena). They CAN'T exaggerate lighting, lines, styles, textures, and expressions. Since they are locked into hyperrealism (often with limited rigging, too, so even then characters look dead-faced and fish-eyed), these comics can only tell you half of a visual story.