This is what I was thinking reading the entire rest of your response! I think that those kinds of things are incredibly important, right now especially, where there's a tendency to draw everything in broad strokes.
I think... what I would look at is, does it feel "too real" to you? Is it something where you're like "this hits too close to home for me right now, I want to tell this story but I don't think I can put my all into it in these current circumstances"? Because if the hesitation comes from being unsure YOU want to jump into it, then that makes sense and, I think, should be respected.
But if you're trying to guess whether it might upset others....... I feel like, someone needs your story really badly right now, with all of its messiness, and it will resonate with them. For someone else, your story will be too much for them. The way I see it, you can't really guess -- it's up to the people reading your story to say "okay, this is starting to touch some themes that hit too close to home right now, I'm going to come back to this some other time" if it's not a good time for them to read that kind of story.
On my twitter feed, there are some people who often tweet calls to action and awareness of problems. There are other people who tweet almost exclusively about silly cartoons and art and cute animals. We need both, and I don't think it's up to any one person to be everything we need. We need a harsh look at truth, and we need comfort and healing. If it's your job to be a truth-teller.... I don't think you have to feel bad just because some of your readers might be seeking comfort instead. There are plenty of other creators who have a story burning in them to comfort and heal, and you don't have to be those people if it's not what's burning in you!
Comics can be escapism, but that's not all they are. People need escapism, but that's not all they need. I dunno, there's not a right or wrong answer, but that's how I feel about it!