I'd be careful about all the colors being thrown around, maybe lower the saturation so they're only slightly tinted because bright colors like the lime green and yellows can be very harsh on the eyes. Two examples of comics that I know use colored speech bubbles for different characters are Patrik the Vampire

and Ava's Demon

Ava's Demon's bubbles tend to be more bright than Patrik's, however the brightest portion is still only around the edges and the area with the main focus of the text is still grayed a little more so it's easy on the eyes. It also matches against the bright backgrounds so it's almost absorbed by the white behind it. Also remember to center your text instead of having it on the left margin in them!
as for the format of the page, it may drive readers off because it's a little odd, but I've seen other comics put a disclaimer saying it's not like that for the whole comic.