Salutatioins! Well, I read through your whole first issue and I've got some things that might help you in future!
I'll start with the art: You've got a good start here in terms of general composition. The only problem I'm having is I can't always tell what's going on in each frame. I can tell you that, this is directly due to a lack of shading. I can't tell foreground from background in some instances and I can't tell objects apart (Reg was sitting in a baby pool in one frame and that is a GREAT visual gag and I totally missed it the first time I saw the page). I'd suggest starting with a grey scale and see how you feel about it. Adding different textures also, will help the foreground pop. So that's how I'd start. One example of this that might help is Mike Mignola. He's the artist for Hellboy and he works primarily in black and white or sparse simple colors. I think you've got a good style in the making and a little bit of shading might make it really pop.
Writing: The writing has some good moments. I love the exchanges between Reg and Iswell, (and the gag that is Iswell's name) they've got some good chemistry going and a believable relationship so far. The scenes are pretty dialogue heavy which isn't always a bad thing but, there's a lot of telling instead of showing that happens. For instance, the Milk Thief. I think this could've come across better if there was a physical representation of this happening before Jack brought it up. For instance: Instead of Jack mentioning to the Catburgler that milk is being stolen out of the fridge, introduce the audience to the joke visually. Have a note pinned to the fridge asking "Who took the milk" or something along those lines so that we've got a subtle hint about it. It reduces dialogue and you can make your exchanges more succinct. Here is some hints on dialogue in comics that I've found useful.
Establishing shots: This one will really help your audience feel the atmosphere. In the segment where Jack, Reg, and Iswell are getting on the boat I actually had no idea they were on a boat, or even a dock. An establishing shot would tell me where we were and give me context. So instead of showing them running across the dock first, instead show a shot of the docks like these show their respective scenes, and it could really open up the atmosphere of the story.
I hope this stuff was helpful. I think you've got a great concept going on with your story and I wish you all the best!