Are we talking about WORKING files, i.e. the hopefully high-res files that you make while actually creating the comic/art? Or are we talking about files for UPLOADING/POSTING?
Working files should never be JPG. Most people save many times while working on a single picture. Every time you save and reopen a JPG, its quality goes down. It will really add up if you do it many times.
PNG isn't the best format for working files, either, due to its lack of layer support. But at least you won't have quality degradation issues.
For posting, I highly recommend saving the same picture you made in JPG and PNG, and comparing the results. If the quality difference is barely noticeable, stick to whichever file that's smaller in size (it will probably be in JPG, unless you save in 8-bit PNG... which is, confusingly, not the same as 8-bit/ 16-bit/ 32-bit colors. Basically 8-bit PNG only supports 256 colors max per pic, like GIF.)
One note: for whatever weird reason, bright, intense reds suffer from huge quality loss when saved in JPG. This isn't just my monitor because I've been noticing this for years, across different computers and screens. So I would recommend saving two pictures each in JPG and PNG for your trial: one picture that has some bright reds in it, and one that doesn't have it.
If you have Photoshop, you can easily preview it without even saving a single time by using the Save for Web function. It will even tell you how big the file size is going to get with your setting and format!
My personal recs:
Uncolored lineart: 8-bit PNG with maybe 32 colors. You lose no visible quality, and the file size is often smaller than it would be in JPG.
Colored lineart: based on the style you use for BioHazard, I would recommend high-ish quality JPG. Your style isn't realistic, but it does have a lot of soft blending. You cannot preserve soft blending in 8-bit PNG. 16-bit PNG will preserve the blending (and everything else) but the filesize will probably be huge.
Try tinkering with the JPG quality setting, too. A low quality JPG and a high quality JPG will look VASTLY different.