First off, Ads will ALWAYS be present on the site regardless of if you have ad-rev activated or not though, so as long as you're hosting here you may as well have ad-rev on.
As for them being inconvenient, it depends on the reader, what ads are being targeted to them and their tolerance levels. Each experience is also going to be different for them as well depending on
- where they live (some ads are country based, some shady ads get through depending on location)
- what browsers they are using (if they're reading on the computer)
- what device they are using (if they are reading on mobile)
- if they had adblock or not
Some of my readers have no issues with the site. Other readers I have the site is completely unreadable because of the ads.
Myself when I'm reading, maybe 75% of the time the ads are just fine, until I run into an ad that will auto redirect me or give me a pop up, or will alert my antivirus software (and yes. It's an ad on the site not something on my computer, this is literally the only site I do not use adblock on and as soon as I turn it on the problem will go away, I usually leave adblock up for a few weeks or a month to wait for the ad to get caught and cleared out and then go back to having no problems on the site)
There's also a glitch on the desktop that will keep jumping me to the next episode (or even the episode after) that makes reading annoying I'm not sure if it's an ad related issue but I suspect that is it cause this problem doesn't happen if I have adblock on.
Depending on the readers tolerance levels to that inconvenience, it could be a make or break issue.
Tapas itself positions it's ads just fine. They're under the comic or at the side, and generally don't intrude with reading.