Yeah BoomerZ nailed it. The more characters you have, the harder it'll be to give them all the time they deserve and then to tie it all off at the end.
Homestuck is a big example of this, where while the ending was really epic, tons of characters had arcs or mysteries set up and never resolved, the fate of some characters was never really clarified and everyone was generally left feeling a little dissatisfied. Hussie did a great job setting up this huge cast of loveable characters, because they treated it like there was no pressing time limit and just rambled around setting up fun stuff with them, but it would have been nearly impossible to finish that story in a way that resolved every character's arc without probably extending the story by months or years, so late on, when Hussie was getting tired and distracted by other projects and wanted Homestuck over, the ending came out rushed and frustrating. Very few people felt like their favourite character/s got a satisfying ending (and don't even get me started on the Epilogues that opened more threads than they closed.... or the awful sequel...
).
Bleach did the same thing, which Kubo Tight even admitted that whenever he felt stuck with the story, he'd introduce a bunch of new characters. This led to the cast just ballooning over time, and interesting characters established early on (like Ichigo's classmates) being sidelined in favour of all the shiny new people. Ultimately a lot of people who'd become really invested in characters from the early volumes and the Soul Society arc, got bored and frustrated because they didn't want these new characters, they wanted more of the characters they already liked, so the reader interest plummeted.
Personally, I try to have the mantras of "Every character might be somebody's favourite character." and "don't invent a new character for a role an existing character could do just fine."
So if I need a character to craft a gadget in Errant, I could introduce a new, wacky "mad scientist" character and that'd be fun, OR I could have the established main cast member, Jules, do it, because we've established that they know about tech. Using Jules is clearly the more economical option here, because I don't need to introduce anyone, and I don't run the risk of having a whole other character the audience wants to see more of to work into other scenes adding a ton of work for myself and bloating the story in a way that could ruin the pacing and make the comic drag on for years. Plus, lots of readers already really like Jules and won't complain about seeing more of them.
I make two pages a week, and I'd rather spend them moving the story and characters I have forward than introducing unnecessary throwaway characters. 