The main pages of my comic are in full color, but most of the side pages are monotone. I can appreciate a comic that's made either way. Both ways have their strengths, but some comics may be better suited to one of them over the other. In the main comic, I went with full color because I thought it suited the tone better.
The side pages being monotone is partly to save some time working on them, but I also wanted to experiment more with working in monotone.