I would not do one panel at a time. It may keep your comic on the front page more regularly, but ultimately reading in such small increments will annoy readers, mess up your pacing, and definitely not lend to a good visual flow from panel to panel.
One of my comics updates with one page per week, and the other with one multi-page (usually about 10) chapter per month. So I feel like I can compare and contrast pretty well.
Page-per-week - This is the most common update style, and the one that most readers are used to, and that websites are based around promoting. It also lets you build up a solid buffer of queued pages (you always want about 3-6 months worth of comic finished and ready to go for when life inevitably gets in the way.). However I think that posting a chapter per week can also really slow the story of a comic to a crawl, especially in dialogue heavy scenes. As a reader I usually read these comics once every couple months, when there's enough pages to really catch up. Numbers wise, you do good views, but the actual audience engagement really heavily varies from page to page.
Chapter-per-Month - As a writer, this is definitely how I prefer to work. It's how most print comics come out, and I wish more webcomics would use this style. Every month you get a much more satisfying update, and is usually much smoother to read. Cons are that these chapters take MUCH longer, so I definitely bump up against my deadlines more often, and since it only pops upon the general feed once a month, you get less new readers, and have to push your word of mouth marketing more. However, I find the readers you do get are more dedicated, I can rely on a steady amount of comments and engagement from my small audience, probably because each chapter is going to have something meaningful.
Also, whichever one you growth,remember your own limits as a writer or artist. It's easy to say that you can post four pages a week or whatever, but unless this is your full-tie job or your pages are super simple get finished super fast, that's a lot harder than it looks. It's all about figuring out what works best for you.