I used to be one of many artists who swore by the hard round brush at varying opacity for everything I drew or painted, but nowadays I experiment with all sorts of brushes. I love browsing Clip Studio assets looking for neat additions to my artistic arsenal.
My recent favorite brush for line art and inking is, hands down, Perfect Pencil by user postdes on the Clip Studio asset store. It's free and it's great.
It may seem counter-intuitive to use a "pencil" to ink, but I just love the texture and versatility of it! I can use it for crisp lines, hazy lines, hatching, smooth shading, etc.
As far as settings go, I always use pressure sensitivity to control the width of my brush. The other important setting is stabilization, which I generally set pretty high unless I need to do some really fine details. I could never go back to working in an art program that does not have a stabilizer!