Oh my gosh, one of my favourite things to do is draw comics in different styles! One of my comic shorts I did in school was faaar different than the style of the comic Time Travelling Sherlock and Hipster Watson I do on Tapas.
This is a page from the other example:
I went rubber hose-y for my Tapas comic, as it's on the goofy end, and I went more with more grungy realism with the above, as it was a heavier topic. Whereas this is the style I usually gravitate toward is different than both those:
Like @punkarsenic said, the style really depends on the tone of the story, which is great as it gives people a chance to experiment and play around. I do run into the issue though, where my variety of styles gets in the way of attracting a specific niche, and can cause confusion for clients. I find that to be more of an issue with illustrations though, as you are marketing toward different clients all the time and it's nice to have a style so they know what to expect. On the other hand, comics may have more flexibility as you are targeting a reader base, who hopefully appreciate you as a storyteller as well and look forward to anything you create. I can't say for sure though, as I'm not an experienced comic artist