Most of the times I lose the will to work on a comic, it's because of the fans responding to the story/message I'm sending in the completely opposite way.
Examples.
Me: I'm going to write a story about races of anthro animals at war, about how stupid and mindless it is to fight one another based on looks, how instead of a side being inherently evil, there's good and bad people on both sides, and you can't let the bad people represent a whole group of people.
Fans: "YES I CAN'T WAIT FOR THEM TO KILL EACH OTHER!!"
"WHICH SIDE ARE YOU ON????"
"OMFG EVERYONE ON ____ IS EVIL THEY DESERVE TO FUCKING DIE! I CAN'T WAIT FOR THEM TO DIE"
"I CAN'T WAIT UNTIL THEY KILL OFF THOSE FKING HORRIBLE ___"
"I"M SO HYPE FOR THE INEVITABLE WAR AND VICTORY OF _____"
Me: Ok... I'm going to work on another story, it'll be about two guys that recently got married and are raising their kids (from one of their first marriages) It'll have all the struggles a family goes through of just growing up together, and kids learning to get used to a new parent. I want it to show how normal same sex marriages are instead of the perception people get that they are all about sex or highly sexual.
Fans: "WHEN ARE THEY GOING TO BANG????"
"URRRGGG SO HOT!!"
"I CAN'T WAIT FOR THE SEX!!!"
"OMG HE'S JAPANESE SO KAWAIIIIIIIIII!!!"
"AHDALJDLSAJDAJDLKSAJDLKASJD GAY BOIS!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!"
"THIS IS HOT I CAN'T WAIT FOR THEM TO FUCK!"