I design rooms so that they're consistent shot to shot, and for small areas I'll keep a mental map of where everything is, but I don't make large maps really. For my story, it's not necessary since the story is very character focused, and they go to like four completely different major sprawling cities in the first 8 issues or so, so I just don't have the time to dig in and lay all of that out and design it. Consistency takes work, and it's not something most people will notice for most things. Hell, I redesign most of the guns and scenery on the fly every time I draw them, and nobody's noticed yet.
Here's an example of how people don't think about spatial consistency: in Jurassic Park, there's a scene where the T-Rex eats a goat that's tied to the ground then escapes his enclosure by breaking through the fence. He eats a car for a while, then pushes that car through the same hole in the fence he just walked through a moment ago, only now it leads to a cliff. This area that was flat ground has now magically turned into a bridge. I love that movie, and I've watched it dozens of times. It took me almost 20 years to notice that glaring problem. People just don't focus on that stuff if they're invested in your story.