I haven't had this happen with a comic (or other story) that I can think of, at least in recent memory, but I have been coming head to head with this kind of situation with an artist I follow on Twitter of late.
Discovered them earlier this year through some Youtube and Twitch content of theirs, love their work, decided to drop them a follow on Twitter. Unfortunately this creator's mental health seems to be in a bad place which is, of course, totally understandable & valid & I hope they are able to begin healing soon but.. man, seeing their social media posts every day borderline makes me want to stop following them ngl x__x
Their posts are just a big ol' cocktail of self depreciation and resentment towards their following and ways that said following interacts with them that they don't appreciate/contributes to said poor mental health. This taps into my feelings about creator self care and being able to identify when you need to step back and take a break for your own well being. It feels (to me at least) like it does more harm spewing essays of constant negativity every day than it would to just say "hey I need to take a social media break. I'll be back if/when I'm ready".
Again it's really too bad because they do awesome work and I haven't unfollowed yet but... maybe I just need to disable notifications from their posts or something for a while @u@;;