I pitched my web comic to three indie publishers after I finished the first issue.
One publisher didn't respond at all.
Two publishers responded with the nicest rejection letters imaginable. Like I actually felt better after reading them. They said the enjoyed reading the issue and gave legitimate reasons for not accepting the submission (the length and full color being too costly, because the story was still in progress and not a self contained work, etc). They also gave some tips about self publishing, crowd funding, and distribution. One of the publishers even shared a link to my webcomic's site on their social media which gave me a nice boost in views!
So, three for three rejections on the project, but the silver lining is sometimes people are nice?