Print-on-demand (POD) is pretty much close to impossible to make any money on. One POD copy for a fully B&W interior 200 page novel can cost between $7 and $15 depending on who you are using. If Amazon sells that copy for you, they're going to take a 15% cut plus charge you an additional $2.41/unit for fulfillment (picking and packing, shipping and handling, CS, and returns).
If your novel sells for $15 in order to be in line with the market, and it cost $15 to POD... no.
This is why so many 1st timers have their novels at $20 or $25 sometimes even $30/copy. Guess what. They do not sell. Not only is a normal reader not willing to pay that amount, that high of a price says that the whole concept is likely an unedited train wreck since the author didn't even bother to learn the basics of the publishing industry.
If you novel sells for $15 and you have $7 in printing it then your net is: $3.34/unit. If you sell 10,000 units that will be $33,400 to pay all of your production and marketing expenses.
If you offset press and perfect bind 1,500 copies of your novel you will pay between $2.50 and $4.50 depending on who you use.
If you novel sells for $13 in order to be more competitive than the rest of the market, then your net is: $6.14/unit. If you sell 12,000 units (because your product is less expensive so there will be more sales), you have $73,680 to pay all of your production and marketing expenses.
POD = vanity and no profits or a loss on each copy sold. Plus POD books use lower quality paper, covers, and binding materials and offer fewer printing options (we only recommend using POD for printing proofs and ARCs). POD perfect bound books often fall apart after several years and their paper will yellow. Very few bookstores will carry POD books. POD is best for people who want to print under 250 copies to show off to their friends and family.
POD books often carry the ISBN of the printer. When you go to list your book on Amazon the publisher of record will be CreateSpace, IngramSpark, etc. which is a giant huge WARNING MOST LIKELY UNEDITED/UNPROFESSIONAL label to readers. Good luck getting any sales from people just browsing and **** no for bookstores carrying it or reviews for that matter.
Offset print = commercial printing for those who want to be a commercial operation. Offset print requires your own ISBN. Your own ISBN = your own small press = more likely a professional operation and a professional product = more sales.
Could spend all day on this...