@hariotezawa, my innocent and lovely little cinnamon roll, you just have a way with words that I will forever admire
As for tips on Twitter activity; I know that following a bunch of random folks that do not interest you or make you want to engage in a conversation is just a waste of time.
What you want to do is maintain focus on what you genuinely love interacting with, as Hario already mentioned, there is a reason to the madness and you will have more fun replying or even retweeting something that makes you happy and excited.
Start out by linking up with your friends, have fun with the GIF section so you can add that extra spice to your tweet.
As for ppl who join in without knowing anyone you can easily search for your favorite things in the world and then like/reply to tweets that are already speaking about this.
Sadly I see too many being scared of the internet and sometimes it can be a bit intimidating, but trust me on this, no one is going to hate on you for liking a tweet about dogs, cats, chocolate, pizza or whatever it is that you love. In fact, ppl will love seeing the engagement just as much as you would if others suddenly started liking and replying to your stuff.
In many cases, we have to shift our focus in order to grant ourselves that one dire wish and when it comes to Twitter, all you have to know is that the moment you like and reply to someone chances are that they will probably respond (unless they are a public figure and have an image to maintain, then it will be difficult), but there might be others with that same thought in the community that will reach out to you.
So, don't b scared, be positive and just have fun
Here is my link again in case you missed it earlier in Hario's post: https://twitter.com/not_minixira