Hi, I made these 2 comic sites in like less than a day, S.elf and Limerence (NSFW)
I didnt really understand wordpress so I decided to use webpagemaker, I totally recommend it. Is easy to use and very intuitive, is kind of like doing a website but graphically instead of using html, but of course for some stuff you need to learn some html..
I will tell you what I used to make these websites:
1.- Web Page maker.
2.- I used to use Ipswitch (A program to upload data to your host) but now that I´m hosting in IWF hosting (The basic hosting is like $4.95 a month, which is great, I use the same host for my 2 webcomics) so now I use IWF hosting instead of Ipswitch.
3.- Namecheap.com, I prefer it to other sites like godaddy.. I have heard bad things about godaddy..
Anyway If I were you I would first go to 000webhost.com, sign for a free website, familiarize myself with web page maker (Or the program of your choice like wordpress) and start playing with it, if you don´t know how to use it look for tutorials or ask me, I will gladly help you 
Also, now that we are discussing doing your own webcomic, could you guys tell me what do you think of the site´s design? Not the comic itself, but the design, like its my first design and as you can see both sites are basically the same.. Could you tell me your opinions?
Thanks in advance.