Yeah... MS5 is pretty much MAGIC to colour with, and the UI has been streamlined and looks a lot neater than the default MS4 version, but I really don't like the changes made to the lettering/panelling tools. It's unfortunate, but I make do by using both programs.
MS4's panelling tool is dead simple too!
Step 1: click on the "Ruler" tab in your layers-panel, and select "Panel ruler layer."
Step 2: Voilá, now you have a darker blue frame sitting on your page, with anchor-points on the corners that can be dragged! This is your work-in-progress version of the panel borders. You can click and drag and change stuff here, before rasterising the layer and making it permanent.
Step 3: You can use the object selector tool to drag the anchor points around, but one big frame does not make a comic-page. You need panels! Click on the panel-cutter tool (the lower red circle) and you get the new options-panel on the right! Tinker with border-widths and gutter-size as you'd like, and click or unclick the 45-degree angle box. Clicking it means the panels will automatically be cut along straight lines (or 45-degree angles), while unclicking it means you can pick any angle you please.
Step 4: Start slicing it up! Then go back to the object selector tool and adjust the size of the panels as you'd like!
Step 5: Rasterise! The insides of your panels are now transparent, and the gutters are solid white.
The panelling tool in MS5 works - you can do a lot of neat things with it, like sliding corners of panels behind other panels, etc., - but I'm so used to to this method that it's hard to switch over. MS4 also allows you to keep the blue-line layer when you create the rasterized layer, so that you can at any time go back to the blue-line layer and tinker with the size of panels if they aren't to your liking.