At first glance, uncomfortable.
Though her expression is calm and smiling, the design (elongated face and neck, strong jaw, lack of irises, sharp cut of clothing) gives me villain-character vibes. Or, at least, a feeling that something is off about her and she's not what she seems.
As I think about it, it might be the mix of long, pointed shapes and rounded edges that has me feeling ambivalent. I've read that in character design, roundness suggests safety and comfort while sharper triangular shapes create an opposite sense of danger, tension, and untrustworthiness. The two together makes it hard to pin down who she is from simply looking.
Anyways, my two cents ^^
