I am not sure how I would feel after I finish a comic and have let my character go and live their life after the main plot. Although my comic Seishin Patona is 1/3 the way complete. (It going to have 16 chapters and I am wrapping up chapter 4) My other comic In The Midst is only on Chapter 2 out of 15 so its still in its infancy. (To be fair Chapter 2 is almost 30 pages long.)
I don't plan to reuse these character after their initial run, I had bad experience with that. I kept reusing one of my favorite OCs Eota and I ended up burning her out. On the bright side I learned how to write better characters for it.
The characters from Seishin Patona and In The Midst may make a cameo appearance in my future work but that will be it.