I had various hillarious reactions from people, mostly because i also explain the premise of my comic.
Most conversations go this way:
Me: i am making a comic online.
Person: about what?
Me: "imagine a classic story about a chosen one saving the world from the forces of evil"
Person: mmm.....okay?
Me: "now replace the protagonist with a rock"
Person (option A): laughs hysterically.
Person: (option B): (looks confused). How does that Work?.
Those two are the most common ones, but every once in a while i get some gems like: "what a time to be alive".