i think once your able to get over it's abstract art style it's a pretty enjoyable watch. I remember watching it on vhs with family as a little kid and even though the monsters were kind of creepy I thought it was pretty cool overall. If anything I think it's odd mixing of style was it's greatest selling point, aside from it featuring music by the Beatles, and was probably perfect having originally come out in i think the late 60s or 70s?
I think that like others have mentioned uncanny valley is the most unsettling. Then there's stuff like G-man from half life, and I've never once played the game but I've seen the one clip everyone seems to quote "Wake up mr. freeman" and anything that resembles that gives me the spooks. There's also Chulip, a video game yes, but between the graphics and probably the atmosphere of the game make it unnerving even if it has a "cute" appearance.