Definitely, parts of the story shift a lot because the characters just decide they don't want to follow my plot points, that they want to add parts to the story I hadn't planned, etc. it just happened with my most recent chapter I was writing like two hours ago.
The biggest released chapter where that happened is "Black Bile" where the female lead was supposed to get depressed, but instead she chose to comfort her sweetheart, and it completely turned the story's tide.
but it's happened in tons of way, the biggest over all way being the fact that my male lead's mother wasn't supposed to be a central character, but she self inserted herself in chapter two and is now the third most important character in the whole story lol.