shake hands really is just a issue with practice for any line art medium. Like it's something that's said again and again, but as long as you focus on making quick strokes with no fear you're fine. Especially if it's digital. there's always the undo button if you don't like it.
@Aetherwing and I would try a freeware program called fire alpaca or medibang paint if you have a mac Medibang is actually pretty useful and similar to MS5 in a lot of ways, so it's a good way to see if it can work with your methods. It comes with a neat tool for making panels too thats pretty simple. you can also download the app version on your phone to do touch ups on the go.