I work full-time and try to manage a social and personal art balance. Considering how much work my comic can be and I don't want to rush, I aim at a bi-weekly update.
Except when I'm starting a new chapter, I can sometimes be on hiatus for a few weeks, while I get all the prep work done. (finalizing the script, layout thumbnails and planning/creating the cover)
I don't have a large following, but the online subscribers I do have, 99.9% stick around for my updates. But, still... most of my readers don't read online, they wait for the book to come out.