If I'm really into something i tend to hyperfocus, so if im really into the book then probably. Most books I really fall into are read in one sitting, (if its a weekend or the summer) though those books are usually around 500 pages.
Though I will add that I've just started reading the way of kings, which is over a thousand pages and I have a feeling this will be a week or more of reading, not because I'm not enjoying it, it's just, like someone else mentioned, there's a lot more "thinking" required