Yeah, do what you wanna do. Though I will add that vertical scroll is not just for mobile. It also reads smoothly on desktop -- just, yeah, not for print.
My comic uses the vertical scroll format. At first, I tried to create a vertical scroll comic that would also print alright by designing print-sized pages that were simply connected to each other at tops and bottoms. This is a viable solution; I know at least one creator who has done this successfully, although her comic is horizontal, not vertical. HOWEVER, I personally found it too hard to accomplish both. It essentially doubled page size limitations, and my storytelling suffered. I scrapped everything from that attempt and started anew.
I'll probably hate myself when I decide to print it (for at-convention promotional purposes), but for now, I feel my comic flows very well, visually.