Hmm well independent comics will have an easier time dealing with piracy since the creator has more control and flexibility. They only have to manage their own title(s), and they get to choose when and how its distributed. Some make their own site, some use password protected links, etc.
While if you're working with a publisher and notice your work is being pirated, more often than not the publisher can't do sh*t (https://twitter.com/rhea_silvan/status/1231825326293962754). And if you as the creator try to confront the problem, you're gonna be met with a lot of rude and entitled behavior. There will always be a group of people that don't care about you they just want free entertainment, but its still worth minimizing the damage.
It's really sad cause a lot of these creators are Japanese/Korean and don't speak english.
But we speak english, and so its easier for us to communicate our audiences and funnel them into a space where they feel as if they are part of a community and the reading experience is more enjoyable/accessible than on piracy sites (no ads, easy to pay, mobile app, etc.). But then the question is how do we provide that?
That's when it get frustrating, because if you're independent chances are you don't have the reach or resources. Best you can do is offer it for free on platforms and then have patron exclusive content. I remember one creator from Webtoon canvas that created their own site and made it pay to read, but I don't think it worked out. Then I guess there's the option of doing regular kickstarters and releasing it as a pdf and print to backers first, which is not a bad way to go about it and many even smaller comic creators have had success with it but its different.
For now, I think most creators just need to focus on growing an audience, trying to get those numbers up, and of course making the best comic they possibly can. Probably this might mean it'll be a few titles and working with publishers before you're big enough to really go "independent". At least, if you're trying to make a sizable income off of this relative to what you'd get working with a publisher. Then tackling piracy will become a real issue.
I don't know if any of this addressed to topic really but as someone who does this full time its something I've considered in my career planning.