This is something I picked up when manga magazine/ inkblazers was around, but I have a habit of instinctively avoiding webcomics that have a Japanese word in the title or have a completely Japanese title. A LOT of the comics there were manga inspired in the absolute worst ways, with either story lines near exact to popular shonen series (just some names and titles changed) left to right panelling but NOT left to right word bubbles, which made reading REALLY REALLY REALLY REALLY REALLY REALLY HARD. Or it was full of romaji every other word (and almost always used badly, awkwardly or incorrectly)
It drove me crazy.
I also find I'll overlook series that have titles that are too long. Unless the whole reason for having a long ass title is for the titles to be taken as a joke. (You can tell the difference)
In general, you want something that can easily be associated with your comic. Fits your series, it simple or unique enough to remember, has a nice ring to it, doesn't sound too much like other series (You want your comic to stand out, not meld in and disappear among similar or other generic titles/themes)