Ye, if it's got a bit of action, some scenes will probably end up being broken down in several "sets" of 4koma strips, all with some punchline. Sometimes you can also divide one panel in two - without the usual gutter - so that adds an extra bit... I've also seen a comic that does parts in 4koma and then switches to usual comic within the chapter (manga called One Week Friends). Of course there's also 6 panel comics... This reminds me of a specific webcomic I read a long time ago;;; It had a pretty serious over-arching story and I'm not even sure each 6-panel update had a joke. Unfortunately, idr what it's called. I know that it's over, has smth akin to magical girls, and there's a power called the Higher Authority.